Hsa_circ_0000092 up-regulates IL24 by SMC1A to induce macrophages M2 polarization
Introduction: Hepatocellular carcinoma (HCC) as the malignant cancers with high morbidity.The EMT of HCC has closely linked to the metastasis and recurrence.Moreover, tumor-associated macrophages (TAMs) can interact with HCC cells in the immune microenvironment; the M2 polarization of TAMs enhance the HCC cells EMT.The mechanism between HCC cells a