Hsa_circ_0000092 up-regulates IL24 by SMC1A to induce macrophages M2 polarization

Hsa_circ_0000092 up-regulates IL24 by SMC1A to induce macrophages M2 polarization

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Introduction: Hepatocellular carcinoma (HCC) as the malignant cancers with high morbidity.The EMT of HCC has closely linked to the metastasis and recurrence.Moreover, tumor-associated macrophages (TAMs) can interact with HCC cells in the immune microenvironment; the M2 polarization of TAMs enhance the HCC cells EMT.The mechanism between HCC cells and TAMs is still unclear and our study was aimed to uncover it.Methods: We performed RT-qPCR and western to detach the RNA and whole wheat phyllo dough protein expression.

The relationship among has_circ_0000092, U2AF2, SMC1A and IL24 were revealed through mechanism experiments.Rescue assays were implemented to determine how circ_0000092 modulates M2 polarization of TAMs.Results: As detected by RT-qPCR, has_circ_0000092 was with high expression in HCC cells and could recruit U2AF2 to promote transcription of SMC1A.Moreover, circ_0000092 could control macrophage M2 polarization via promoting IL24 expression in HCC cells.Conclusion: To conclude, guerlain ideal cologne hsa_circ_0000092 can up-regulates IL24 by SMC1A to induce macrophages M2 polarization.